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Para ser grande, Sê inteiro: nada
Teu exagera ou exclui.
Sê todo em cada coisa. Põe quanto és
No mínimo que fazes.
Assim em cada lago a Lua toda
Brilha, porque alta vive.
To be great, be whole: exclude
Nothing, exaggerate nothing that is you.
Be whole in everything. Put all you are
Into the smallest thing you do.
The whole moon gleams in every pool,
It rides so high.
Ricardo Reis, Fernando Pessoa, Oito Odes da 'Presenca'
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CV |
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10/2006 - present
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PhD
J.W. Goethe Universität, Frankfurt am Main, Germany
Supervisor: Dr. Holger Gohlke
Computational Pharmaceutical Chemistry Group
Christian-Albrechts-Universität, Kiel, Germany
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7/2006 - 12/2006
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Fa. Merz Pharma GmbH & Co. KGaA
Internship, freelancing, advisory activity
Topic: Homology model-based virtual screening for GPCR ligands
Frankfurt am Main, Germany
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11/2005 - 6/2006
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CPGS (Certificate of Postgraduate Study)
Topic: Protein-ligand interactions
Supervisor: Prof. Dr. R.C. Glen
Unilever Centre for Molecular Science Informatics
University Chemical Laboratory, University of Cambridge, UK
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3/2005 - 9/2005
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Diploma thesis
Topic: Molecular dynamics simulations of unfolded protein states
Supervisor: Dr. Holger Gohlke
Molecular Bioinformatics Group
J.W. Goethe Universität, Frankfurt am Main, Germany
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10/2002 - 9/2005
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Hauptstudium in Bioinformatics (Diplom)
J.W. Goethe Universität, Frankfurt am Main, Germany
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10/2000 - 9/2002
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Grundstudium in Bioinformatics (Vordiplom)
J.W. Goethe Universität, Frankfurt am Main, Germany
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9/1999 - 6/2000
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Civilian service
Institute for Anthropology und Human Genetics
Eberhard-Karls-Universität, Tübingen, Germany
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2/1997 - 9/2001
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Schwarzwälder Bote, Newspaper for Baden-Württemberg
Freelancing, local editorial office
Rottweil, Germany
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7/1990 - 6/1999
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High school graduation (Abitur)
Albertus-Magnus-Gymnasium, Rottweil, Germany
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Teaching |
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10/2002 - present
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Tutoring in Informatics and Theoretical Chemistry for first-year students (Informatics, Bioinformatics, Chemistry) at J.W. Goethe University, Frankfurt, Germany, and University of Cambridge, UK.
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Skills |
Programming: Java, C++, Perl, Python, R
Software: Amber, Pymol, Moloc, Sybyl, DrugScore, AutoDock, Gamess
Spoken languages: German, Italian, English, introductory Russian und Farsi
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Publications |
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| Articles |
6. Radestock, S., Gohlke, H. Exploiting the link between protein rigidity and thermostability for data-driven protein engineering. Engineering in Life Sciences 2008, 8, 507-522. new!
5. Radestock, S., Gohlke, H. Constraint network analysis: Exploiting the link between protein rigidity and thermostability. Conference Proceedings: From Computational Biophysics to Systems Biology, NIC Series Vol. 40, Hansmann, U.H.E. et al. (Eds.), 2008, 357-360. [Full text]
4. Radestock, S., Weil, T., Renner, S. Homology model-based virtual screening for GPCR ligands using docking and target-biased scoring. Journal of Chemical Information and Modeling 2008, 48,1104-1117. [Abstract]
3. Renner, S., Derksen, S., Radestock, S., Mörchen, F. Maximum common binding modes (MCBM): Consensus docking scoring using multiple ligand information and interaction fingerprints. Journal of Chemical Information and Modeling 2008, 48, 319-332. [Abstract]
2. Radestock, S., Gohlke, H. Molekulare Bioinformatik in der Pharmaforschung. Bioforum 2007, 3, 50-52. [Full text]
1. Radestock, S., Böhm, M., Gohlke, H. Improving binding mode predictions by docking into protein-specifically adapted potential fields. Journal of Medicinal Chemistry 2005, 48, 5466-5479. [Abstract] [Full text]
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| Posters |
9. Radestock, S., Gohlke, H. Constraint network analysis: A computational framework for characterizing protein stability features. Poster at the Workshop "From Computational Biophysics to System Biology", Jülich, Germany, May 19th-21st, 2008. [Abstract]
8. Dejung, M., Radestock, S., Gohlke, H. Web interface with advanced query properties for the Binding Interface (BIF) database. Poster at the 22nd Darmstadt Molecular Modeling Workshop, Erlangen, Germany, April 29th-30th, 2008. [Abstract]
7. Radestock, S., Gohlke, H. Structure network analysis: A computational framework for characterizing protein stability features. Poster at the 2nd International Symposium on Biothermodynamics, Frankfurt a.M., Germany, February 21st-22nd, 2008.
6. Radestock, S., Gohlke, H. Percolation behavior of structure networks from thermostable proteins. Poster at the Indo-German Conference on Modeling Chemical and Biological (Re)Activity, Hyderabad, India, September 26th-29th, 2007. [Abstract]
5. Koller, A.N., Radestock, S., Gohlke, H. Characterization of the unfolded state of hen lysozyme by combining MD and NMR. Poster at the Computer Simulation and Theory of Macromolecules 2007 Workshop, Hünfeld, Germany, April 20th-22nd, 2007.
4. Radestock, S., Gohlke, H. The unfolded state of lysozyme: A replica exchange molecular dynamics simulation. Poster at the Methods in Molecular Simulation 2006 Workshop, Heidelberg, Germany, September 20th-22nd, 2006.
3. Radestock, S., Gohlke, H. Molecular dynamics simulations of unfolded protein states. Poster at the EMBO Workshop on Biomolecular Simulation, Paris, France, June 27th - July 4th, 2006.
2. Radestock, S., Gohlke, H. Molecular dynamics simulations of unfolded protein states. Poster at the 20th Darmstadt Molecular Modeling Workshop, Erlangen, Germany, May 23rd-24th, 2006. [Abstract]
1. Radestock, S., Böhm, M., Gohlke, H. Improving binding mode predictions by docking into protein-specifically adapted potential fields. Poster at the 18th CIC-Workshop of the Gesellschaft Deutscher Chemiker (GDCh), Boppard, Germany, November 14th-15th, 2004. [Abstract]
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| Talks |
5. Constraint network analysis: Exploiting the link between protein rigidity and thermostability. Talk at the Methods in Molecular Simulation Workshop, Heidelberg, Germany, October 8th-10th, 2008.
4. Constraint network analysis: Exploiting the link between protein rigidity and thermostability. Talk at the 22nd Darmstadt Molecular Modeling Workshop, Erlangen, Germany, April 29th-30th, 2008. [Abstract]
3. Homology model-based virtual screening for GPCR ligands using docking and target-biased scoring. Talk at the Young Modelers' Forum, London, UK, November 30th, 2007.
2. Homology model-based virtual screening for GPCR ligands using docking and target-biased scoring. Talk at the 21st Darmstadt Molecular Modeling Workshop, Erlangen, Germany, May 15th-16th, 2007. [Abstract]
1. Improving binding mode predictions by docking into protein-specifically adapted potential fields. Talk at the 19th Darmstadt Molecular Modeling Workshop, Erlangen, Germany, May 3rd-4th, 2005. [Abstract]
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Awards and scholarships |
5/2007: 1st prize from the Molecular Graphics and Modeling Society - Deutsche Sektion - for a talk hold at the 21st Darmstadt Molecular Modeling Workshop, Erlangen, Germany, May 15th, 2007
12/2006 - present: PhD scholarship from the J.W. Goethe-University, Frankfurt am Main, Germany
9/2006: Prize for a poster presented at the Methods in Molecular Simulation 2006 Workshop, Heidelberg, Germany, September 20th, 2006
5/2006: Prize from the Molecular Graphics and Modeling Society - Deutsche Sektion - for a poster presented at the 20th Darmstadt Molecular Modeling Workshop, Erlangen, Germany, May 23rd, 2006
6/2005 - 9/2005: Scholarship from the Degussa foundation, Düsseldorf
5/2005: 2nd prize from the Molecular Graphics and Modeling Society - Deutsche Sektion - for a talk hold at the 19th Darmstadt Molecular Modeling Workshop, Erlangen, Germany, May 4th, 2005
2/2001 - 11/2004: e-fellows scholarship
1999: Prize of the "Fond der Chemischen Industrie" for best high school gradiation (Abitur) in chemistry
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